Collection: Compounded GLP-1: Side Effects & How to Alleviate Them

Maintaining a healthy weight can be challenging, especially when diet and exercise alone don’t yield your desired results. For individuals struggling with obesity or weight-related health conditions, tirzepatide has emerged as a promising treatment. Originally developed for managing type 2 diabetes, this compounded medication is now widely prescribed for weight loss due to its ability to regulate appetite and metabolism.

At Vaera Essence, our team offers GLP-1 treatments in the Philippines as part of our comprehensive approach to weight management. If you’re considering this treatment, it’s important to understand how tirzepatide work, what side effects to expect, and how to minimize any discomfort.

What is Tirzepatide and How Does It Work?

Tirzepatide is both GLP-1 and GIP receptor agonists, meaning they mimic the hormone glucagon-like peptide-1 (GLP-1), which plays a crucial role in regulating blood sugar, digestion, and appetite. When taken as part of a structured weight loss program, it can help control food cravings, slow stomach emptying, and enhance insulin function, making it easier to maintain a calorie deficit for weight loss.

By slowing the movement of food through the digestive system, tirzepatide extend feelings of fullness, helping patients naturally reduce their calorie intake. However, this slowed digestion can also lead to gastrointestinal side effects, especially during the initial weeks of treatment.

Common Side Effects of Tirzepatide

Like any medication, tirzepatide may cause side effects as the body adjusts. Most symptoms are mild to moderate and improve over time. However, knowing what to expect can help you manage these side effects effectively.

The Most Frequently Reported Side Effects

• Nausea: As food moves more slowly through the stomach, some patients experience nausea, especially after eating large or rich meals.
• Vomiting: In some cases, nausea may lead to occasional vomiting, particularly when the dosage is increased.
• Diarrhea: A shift in digestion can cause loose stools in the first few weeks of treatment.
• Constipation: While some patients experience diarrhea, others may find that digestion slows too much, leading to constipation.
• Loss of Appetite: A reduced interest in food is a common effect of tirzepatide, sometimes making it difficult to meet nutritional needs.
• Fatigue: The body’s adjustment to lower food intake and metabolic changes can cause temporary tiredness.
• Headaches: Dehydration or blood sugar fluctuations can lead to headaches.

Less Common but Serious Side Effects

While rare, some individuals may experience more serious reactions, including:

• Severe dehydration: If nausea, vomiting, or diarrhea conditions persist, dehydration can become a risk.
• Pancreatitis: Severe abdominal pain, nausea, and vomiting may indicate inflammation of the pancreas.
• Gallbladder issues: Rapid weight loss can sometimes contribute to gallstones or gallbladder dysfunction.
• Vision changes: Individuals with diabetes should monitor for changes in eyesight, as blood sugar fluctuations can affect vision.
• Allergic reactions: Though extremely rare, swelling, difficulty breathing, or a rash may indicate an allergic response that requires immediate medical attention.

How to Minimize and Manage and Tirzepatide Side Effects

While some side effects are unavoidable as your body adapts to tirzepatide, there are effective strategies to reduce discomfort and improve your experience with the medication.

1. Managing Nausea and Digestive Discomfort

• Eat smaller, more frequent meals: Large portions can trigger nausea, so focus on eating smaller meals throughout the day.
• Avoid greasy, fried, or highly processed foods: Fatty foods take longer to digest and can worsen nausea.
• Stay hydrated: Drinking plenty of water helps digestion and prevents dehydration from nausea or diarrhea.
• Try ginger or peppermint: These natural remedies can soothe nausea and improve digestion.

2. Preventing Constipation or Diarrhea

• Increase fiber gradually: Eating fiber-rich foods like vegetables, whole grains, and legumes can help regulate bowel movements.
• Drink more fluids: Staying hydrated is key to preventing both diarrhea and constipation.
• Engage in light activity: Gentle movement, such as walking after meals, helps stimulate digestion.

3. Reducing Fatigue and Headaches

• Prioritize sleep: Getting enough rest is crucial as your body adjusts to metabolic changes.
• Maintain balanced blood sugar: Avoid skipping meals and choose nutrient-dense foods to maintain energy levels.
• Monitor hydration levels: Headaches are often a sign of dehydration, so ensure you’re drinking enough water daily.

As you can see, managing side effects largely comes down to eating well, being well-rested, and ensuring you have plenty of hydration.

At Vaera Essence,  we are committed to helping clients achieve their weight loss goals safely and effectively. If you’re ready to take the next step toward lasting weight management, send us a message or complete our online intake form today!